I retired in 2016 from a Readership in Cancer Biology in the Department of Pathology, although I still teach and research part time. My research has been on breast and oesophageal cancer, and in recent years has focused on ‘sequencing cancer genomes’, i.e., trying to find out what has happened to the cancer cells’ DNA to cause the cancer. My particular interest has been the large-scale rearrangements of DNA, such as chromosome translocations. These are important but still not well analysed, because current DNA sequencing generates a lot of short bits of sequence that cannot easily be strung together. I have also used DNA sequencing to map DNA in 3-D in the cell nucleus.
Selected recent publications:
RA Beagrie, A Scialdone, M Schueler, DCA Kraemer, M Chotalia, SQ Xie, M Barbieri, I de Santiago, L-M Lavitas, MR Branco, JF, JDostie, L Game, N Dillon, PAW Edwards, M Nicodemi, A Pombo. Complex multi-enhancer contacts captured by Genome Architecture Mapping (GAM) Nature 2017;543,519-524
Mason B, Flach S, Teixeira FR, Manzano Garcia R, Rueda OM, Abraham JE, Caldas C, Edwards PAW, Laman, H. Cell. Mol. Life Sci. (2019). Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.
One of 46 named authors. Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours. Nature Genetics, 2020; 52, 306-319
Karen D. Howarth, Tashfina Mirza, Susanna L. Cooke, Suet-Feung Chin, Jessica C. Pole, Ernest Turro, Matthew D. Eldridge, Raquel Manzano Garcia, Oscar M. Rueda, Chris Boursnell, Jean E. Abraham, Carlos Caldas and Paul A. W. Edwards. NRG1 fusions in breast cancer. Breast Cancer Research 2021; 23:3
Ng AWT, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, Su J, Redmond AM, Weaver JMJ, Eldridge MD, Simon Tavaré S, Molecular Stratification (OCCAMS) Consortium, Edwards PAW, Fitzgerald RC. Rearrangement processes and structural variations show evidence of selection in